Regulation of life and death by the zinc finger transcription factor Egr‐1
Identifieur interne : 000C41 ( Main/Exploration ); précédent : 000C40; suivant : 000C42Regulation of life and death by the zinc finger transcription factor Egr‐1
Auteurs : Gerald Thiel [Allemagne] ; Giuseppe Cibelli [Allemagne, Italie]Source :
- Journal of Cellular Physiology [ 0021-9541 ] ; 2002-12.
English descriptors
- Teeft :
- Activation, Activation domain, Adamson, Anking region, Apoptosis, Autocrine loop, Binding site, Binding sites, Biochem, Biol, Biol chem, Biological activity, Biological functions, Biosynthesis, Brosarcoma cells, Cell biol, Cell death, Cell growth, Cell survival, Cellular proliferation, Chem, Cibelli, Counteracts apoptosis, Early growth response, Epidermal growth factor, Extensive activation domain, Gene, Gene expression, Gene transcription, Genetic elements, Gerdes thiel, Glioma cells, Growth control, Growth factor, Growth factor synthesis, Growth factors, Human neuroblastoma cells, Human promoter, Inhibitory domain, Kaufmann, Kinase, Knockout mice, Lipid phosphatase pten, Many cell types, Medical biochemistry, Milbrandt, Modular structure, Molecular biology, Multistage carcinogenesis, Nab1, Nab2, Neuronal apoptosis, Neuronal cell death, Nger, Nger motifs, Nger transcription factor, Pathway, Physiological parameters, Plateletderived growth factor, Proc natl acad, Promoter, Promoter activity, Protein kinase, Pten, Pten gene, Pten promoter, Pten synthesis, Response element, Serum response elements, Sukhatme, Svaren, Target genes, Thiel, Transcription, Transcription factor, Transcription factors, Transcriptional, Transcriptional activation, Tumor growth, Tumor suppressor protein, Ultraviolet light.
Abstract
The biosynthesis of the zinc finger transcription factor Egr‐1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5′‐flanking region of the Egr‐1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr‐1 gene, and subsequently, transcription of Egr‐1‐responsive genes. Thus, Egr‐1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr‐1. Here, we discuss evidence for Egr‐1 control of cellular proliferation and programmed cell death. J. Cell. Physiol. 193: 287–292, 2002. © 2002 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jcp.10178
Affiliations:
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Cell. Physiol.</title><idno type="ISSN">0021-9541</idno><idno type="eISSN">1097-4652</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-12">2002-12</date><biblScope unit="volume">193</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="292">292</biblScope></imprint><idno type="ISSN">0021-9541</idno></series><idno type="istex">7C70296D46BCF99982A0B16531F96FC199885AC8</idno><idno type="DOI">10.1002/jcp.10178</idno><idno type="ArticleID">JCP10178</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9541</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activation</term><term>Activation domain</term><term>Adamson</term><term>Anking region</term><term>Apoptosis</term><term>Autocrine loop</term><term>Binding site</term><term>Binding sites</term><term>Biochem</term><term>Biol</term><term>Biol chem</term><term>Biological activity</term><term>Biological functions</term><term>Biosynthesis</term><term>Brosarcoma cells</term><term>Cell biol</term><term>Cell death</term><term>Cell growth</term><term>Cell survival</term><term>Cellular proliferation</term><term>Chem</term><term>Cibelli</term><term>Counteracts apoptosis</term><term>Early growth response</term><term>Epidermal growth factor</term><term>Extensive activation domain</term><term>Gene</term><term>Gene expression</term><term>Gene transcription</term><term>Genetic elements</term><term>Gerdes thiel</term><term>Glioma cells</term><term>Growth control</term><term>Growth factor</term><term>Growth factor synthesis</term><term>Growth factors</term><term>Human neuroblastoma cells</term><term>Human promoter</term><term>Inhibitory domain</term><term>Kaufmann</term><term>Kinase</term><term>Knockout mice</term><term>Lipid phosphatase pten</term><term>Many cell types</term><term>Medical biochemistry</term><term>Milbrandt</term><term>Modular structure</term><term>Molecular biology</term><term>Multistage carcinogenesis</term><term>Nab1</term><term>Nab2</term><term>Neuronal apoptosis</term><term>Neuronal cell death</term><term>Nger</term><term>Nger motifs</term><term>Nger transcription factor</term><term>Pathway</term><term>Physiological parameters</term><term>Plateletderived growth factor</term><term>Proc natl acad</term><term>Promoter</term><term>Promoter activity</term><term>Protein kinase</term><term>Pten</term><term>Pten gene</term><term>Pten promoter</term><term>Pten synthesis</term><term>Response element</term><term>Serum response elements</term><term>Sukhatme</term><term>Svaren</term><term>Target genes</term><term>Thiel</term><term>Transcription</term><term>Transcription factor</term><term>Transcription factors</term><term>Transcriptional</term><term>Transcriptional activation</term><term>Tumor growth</term><term>Tumor suppressor protein</term><term>Ultraviolet light</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The biosynthesis of the zinc finger transcription factor Egr‐1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5′‐flanking region of the Egr‐1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr‐1 gene, and subsequently, transcription of Egr‐1‐responsive genes. Thus, Egr‐1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr‐1. Here, we discuss evidence for Egr‐1 control of cellular proliferation and programmed cell death. J. Cell. Physiol. 193: 287–292, 2002. © 2002 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Thiel, Gerald" sort="Thiel, Gerald" uniqKey="Thiel G" first="Gerald" last="Thiel">Gerald Thiel</name></noRegion><name sortKey="Cibelli, Giuseppe" sort="Cibelli, Giuseppe" uniqKey="Cibelli G" first="Giuseppe" last="Cibelli">Giuseppe Cibelli</name><name sortKey="Thiel, Gerald" sort="Thiel, Gerald" uniqKey="Thiel G" first="Gerald" last="Thiel">Gerald Thiel</name></country><country name="Italie"><noRegion><name sortKey="Cibelli, Giuseppe" sort="Cibelli, Giuseppe" uniqKey="Cibelli G" first="Giuseppe" last="Cibelli">Giuseppe Cibelli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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